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Unleashing Bioavailability
Particle Size, Salt Form, and Disproportionation
Salt formation increases API solubility but often fails due to disproportionation, where salts revert to insoluble forms in the body. This whitepaper shows how aggressive particle size reduction (<10 µm) speeds up dissolution enough to "beat the clock," ensuring maximum absorption before disproportionation occurs.
- Beat the Clock: Reduce particle size to <10 µm to achieve full dissolution within 80 seconds.
- Prevent Solubility Loss: Stop salts from reverting to insoluble free forms during absorption.
- Low-Material Testing: Use Single Particle Analysis (SPA®) to get critical data with less than 100 µg of material.