Co-Jet Milling Whitepaper
Improve blending uniformity and powder flow by combining milling and mixing into a single, efficient process.
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Feeder Selection for Micronization Whitepaper
Minimize material loss and ensure precise feed rates during early-phase development by selecting the right feeder technology.
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Unleashing Bioavailability Whitepaper
Maximize absorption by using particle size reduction to achieve full dissolution before salt disproportionation occurs.
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Developing Robust PSD Methods via Laser Diffraction Whitepaper
Ensure accurate data by selecting the optimal wet or dry dispersion techniques for your specific API properties.
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Prevent dehydration and phase changes in API hydrates using humidified air-swept classification.
API hydrates face significant risks during micronization, as mechanical heat and dry gases can cause dehydration and unwanted phase conversions.
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Adding SYLOID® Mesoporous Silicato Improve Run Time and Yield forMicronization Processes
Feed rate is one of the two main operating parameters in a jet milling process and consistent feed rates lead to a more homogeneous final product. Adding SYLOID® mesoporous silica at low percentages to a micronization process improves feed rate consistency. Mill retention can also lead to low yields and long run times. The addition of silica can reduce mill retention, increase yields, and improve process efficiencies.
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Using SYLOID® Mesoporous Silica as an Additive to Mitigate Powder Flow and Static Issues in Micronization Processes
Jet-milled powders often have a high level of static and poor powder flow properties, which presents difficulties for downstream formulation. Adding SYLOID® mesoporous silica at low percentages to a micronization process can address these disadvantages and lead to better blended downstream products.
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